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  • 产品名称:Phospho-LPIN1(Thr14) AntibodyAffinity/磷酸化/AF7085/100ul现货

  • 产品型号:AF7085
  • 产品厂商:Affinity
  • 产品价格:2500
  • 折扣价格:0
  • 产品文档:
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简单介绍:
Phospho-LPIN1(Thr14) AntibodyAffinity/磷酸化/AF7085/100ul现货 Affinity全球*全*新磷酸化抗体,可出具HPLC/MS检测报告,WB检测采用封闭钛验证。ELISE保证,IHC验证人大小鼠超过81种不同组织。 Phospho-LPIN1(Thr14) AntibodyAffinity/磷酸化/AF7085/100ul现货 Phospho-LPIN1(Thr14) AntibodyAffinity/磷酸化/AF7085/100ul现货
详情介绍:

Phospho-LPIN1(Thr14) AntibodyAffinity/磷酸化/AF7085/100ul现货


别名:

EC=3.1.3.4; KIAA0188; Lipin-1; Lpin1; LPIN1_HUMAN; PAP1; Phosphatidate phosphatase LPIN1;

应用:

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

反应种属:

Human,Mouse,Rat

纯化:

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

表位:

Phospho-LPIN1(Thr14) Antibody detects endogenous levels of LPIN1 only when phosphorylated at Thr14

**原:

A synthesized peptide derived from human LPIN1 around the phosphorylation site of Thr14

研究领域:

· Environmental Inion Processing > Signal transduction > mTOR signaling pathway(查看通路图)
· Metabolism > Lipid metabolism > Glycerophospholipid metabolism
· Metabolism > Lipid metabolism > Glycerolipid metabolism
· Metabolism > Global and overview maps > Metabolic pathways

功能:

Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity).

细胞定位:

Cytosol;Endoplasmic reticulum;Mitochondrion;Nucleus;

Extracellular region or secretedCytosolPlasma membraneCytoskeletonLysosomeEndosomePeroxisomeERGolgi apparatusNucleusMitochondrionManual annotationAutomatic computational assertionGraphics by Christian Stolte

翻译后修饰:

Phosphorylated at multiple sites in response to insulin. Phosphorylation is controlled by the mTOR signaling pathway. Phosphorylation is decreased by epinephrine. Phosphorylation may not directly affect the catalytic activity but may regulate the localization. Dephosphorylated by the CTDNEP1-CNEP1R1 complex (By similarity).Sumoylated.

组织特异性:

Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract.

亚结构:

Interacts (via LXXIL motif) with PPARA. Interacts with PPARGC1A. Interaction with PPARA and PPARGC1A leads to the ion of a complex that modulates gene transcription. Interacts with MEF2C.

同源性:

Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL), a transcriptional binding motif, which tes interaction with PPARA.Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif essential for phosphatidate phosphatase activity.Belongs to the lipin family.

Protein BLAST With

蛋白序列:

        10         20         30         40         50
MNYVGQLAGQ VFVTVKELYK GLNPATLSGC IDIIVIRQPN GNLQCSPFHV 
        60         70         80         90        100
RFGKMGVLRS REKVVDIEIN GESVDLHMKL GDNGEAFFVQ ETDNDQEVIP 
       110        120        130        140        150
MHLATSPILS EGASRMECQL KRGSVDRMRG LDPSTPAQVI APSETPSSSS 
       160        170        180        190        200
VVKKRRKRRR KSQLDSLKRD DNMNTSEDED MFPIEMSSDE AMELLESSRT 
       210        220        230        240        250
LPNDIPPFQD DIPEENLSLA VIYPQSASYP NSDREWSPTP SPSGSRPSTP 
       260        270        280        290        300
KSDSELVSKS TERTGQKNPE MLWLWGELPQ AAKSSSPHKM KESSPLSSRK 
       310        320        330        340        350
ICDKSHFQAI HSESSDTFSD QSPTLVGGAL LDQNKPQTEM QFVNEEDLET 
       360        370        380        390        400
LGAAAPLLPM IEELKPPSAS VVQTANKTDS PSRKRDKRSR HLGADGVYLD 
       410        420        430        440        450
DLTDMDPEVA ALYFPKNGDP SGLAKHASDN GARSANQSPQ SVGSSGVDSG 
       460        470        480        490        500
VESTSDGLRD LPSIAISLCG GLSDHREITK DAFLEQAVSY QQFVDNPAII 
       510        520        530        540        550
DDPNLVVKIG SKYYNWTTAA PLLLAMQAFQ KPLPKATVES IMRDKMPKKG 
       560        570        580        590        600
GRWWFSWRGR NTTIKEESKP EQCLAGKAHS TGEQPPQLSL ATRVKHESSS 
       610        620        630        640        650
SDEERAAAKP SNAGHLPLLP NVSYKKTLRL TSEQLKSLKL KNGPNDVVFS 
       660        670        680        690        700
VTTQYQGTCR CEGTIYLWNW DDKVIISDID GTITRSDTLG HILPTLGKDW 
       710        720        730        740        750
THQGIAKLYH KVSQNGYKFL YCSARAIGMA DMTRGYLHWV NERGTVLPQG 
       760        770        780        790        800
PLLLSPSSLF SALHREVIEK KPEKFKVQCL TDIKNLFFPN TEPFYAAFGN 
       810        820        830        840        850
RPADVYSYKQ VGVSLNRIFT VNPKGELVQE HAKTNISSYV RLCEVVDHVF 
       860        870        880        890
PLLKRSHSSD FPCSDTFSNF TFWREPLPPF ENQDIHSASA            

保存说明:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt


Phospho-LPIN1(Thr14) AntibodyAffinity/磷酸化/AF7085/100ul现货Phospho-LPIN1(Thr14) AntibodyAffinity/磷酸化/AF7085/100ul现货

Phospho-LPIN1(Thr14) AntibodyAffinity/磷酸化/AF7085/100ul现货Phospho-LPIN1(Thr14) AntibodyAffinity/磷酸化/AF7085/100ul现货

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