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  • 产品名称:Phospho-CUL4B(Thr48) Antibody/Affinity/磷酸化/AF7083/100ul现货

  • 产品型号:AF7083
  • 产品厂商:Affinity
  • 产品价格:2500
  • 折扣价格:0
  • 产品文档:
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简单介绍:
Phospho-CUL4B(Thr48) Antibody/Affinity/磷酸化/AF7083/100ul现货 Affinity全球*全*新磷酸化抗体,可出具HPLC/MS检测报告,WB检测采用封闭钛验证。ELISE保证,IHC验证人大小鼠超过79种不同组织。 Phospho-CUL4B(Thr48) Antibody/Affinity/磷酸化/AF7083/100ul现货 Phospho-CUL4B(Thr48) Antibody/Affinity/磷酸化/AF7083/100ul现货
详情介绍:

Phospho-CUL4B(Thr48) Antibody/Affinity/磷酸化/AF7083/100ul现货


别名:

CUL 4B; CUL-4B; CUL4B; CUL4B_HUMAN; Cullin-4B; DKFZp686F1470; KIAA0695; MRXHF2; MRXSC; S***;

应用:

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

反应种属:

Human

纯化:

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

表位:

Phospho-CUL4B(Thr48) Antibody detects endogenous levels of CUL4B only when phosphorylated at Thr48

**原:

A synthesized peptide derived from human CUL4B around the phosphorylation site of Thr48

研究领域:

· Genetic Inion Processing > Replication and repair > Nucleotide excision repair
· Genetic Inion Processing > Folding, sorting and degradation > Ubiquitin ted proteolysis(查看通路图)

功能:

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which te the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-ted pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.

细胞定位:

Cytosol;Extracellular region or secreted;Nucleus;

Extracellular region or secretedCytosolPlasma membraneCytoskeletonLysosomeEndosomePeroxisomeERGolgi apparatusNucleusMitochondrionManual annotationAutomatic computational assertionGraphics by Christian Stolte

翻译后修饰:

Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.

亚结构:

Component of multiple DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes that seem to be formed of DDB1, CUL4A or CUL4B, RBX1 and a variable substrate recognition component which seems to belong to a protein family described as DCAF (Ddb1- and Cul4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins. Component of the DCX(DTL) complex with the putative substrate recognition component DTL. Component of the DCX(DDB2) complex with the putative substrate recognition component DDB2. Part of a complex with RBX1 and TIP120A/CAND1. Interacts with RBX1 GRWD1, MLST8, SMU1, TLE2, TLE3, DCAF1, DDA1, DCAF6, DCAF17, DDB2, DCAF8, TIP120A/CAND1 and TMEM113. Interacts with cyclin E and with importins alpha-1 (KPNA2), alpha-3 (KPNA4), alpha-5 (KPNA1) and beta-1 (KPNB1). May interact with WDR26, WDR51B, SNRNP40, WDR61, WDR76 and WDR5.

同源性:

Belongs to the cullin family.

Protein BLAST With

蛋白序列:

        10         20         30         40         50
MMSQSSGSGD GNDDEATTSK DGGFSSPSPS AAAAAQEVRS ATDGNTSTTP 
        60         70         80         90        100
PTSAKKRKLN SSSSSSSNSS NEREDFDSTS SSSSTPPLQP RDSASPSTSS 
       110        120        130        140        150
FCLGVSVAAS SHVPIQKKLR FEDTLEFVGF DAKMAEESSS SSSSSSPTAA 
       160        170        180        190        200
TSQQQQLKNK SILISSVASV HHANGLAKSS TTVSSFANSK PGSAKKLVIK 
       210        220        230        240        250
NFKDKPKLPE NYTDETWQKL KEAVEAIQNS TSIKYNLEEL YQAVENLCSY 
       260        270        280        290        300
KISANLYKQL RQICEDHIKA QIHQFREDSL DSVLFLKKID RCWQNHCRQM 
       310        320        330        340        350
IMIRSIFLFL DRTYVLQNSM LPSIWDMGLE LFRAHIISDQ KVQNKTIDGI 
       360        370        380        390        400
LLLIERERNG EAIDRSLLRS LLSMLSDLQI YQDSFEQRFL EETNRLYAAE 
       410        420        430        440        450
GQKLMQEREV PEYLHHVNKR LEEEADRLIT YLDQTTQKSL IATVEKQLLG 
       460        470        480        490        500
EHLTAILQKG LNNLLDENRI QDLSLLYQLF SRVRGGVQVL LQQWIEYIKA 
       510        520        530        540        550
FGSTIVINPE KDKTMVQELL DFKDKVDHII DICFLKNEKF INAMKEAFET 
       560        570        580        590        600
FINKRPNKPA ELIAKYVDSK LRAGNKEATD EELEKMLDKI MIIFRFIYGK 
       610        620        630        640        650
DVFEAFYKKD LAKRLLVGKS ASVDAEKSML SKLKHECGAA FTSKLEGMFK 
       660        670        680        690        700
DMELSKDIMI QFKQYMQNQN VPGNIELTVN ILTMGYWPTY VPMEVHLPPE 
       710        720        730        740        750
MVKLQEIFKT FYLGKHSGRK LQWQSTLGHC VLKAEFKEGK KELQVSLFQT 
       760        770        780        790        800
LVLLMFNEGE EFSLEEIKQA TGIEDGELRR TLQSLACGKA RVLAKNPKGK 
       810        820        830        840        850
DIEDGDKFIC NDDFKHKLFR IKINQIQMKE TVEEQASTTE RVFQDRQYQI 
       860        870        880        890        900
DAAIVRIMKM RKTLSHNLLV SEVYNQLKFP VKPADLKKRI ESLIDRDYME 
       910 
RDKENPNQYN YIA                                  

保存说明:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt


Phospho-CUL4B(Thr48) Antibody/Affinity/磷酸化/AF7083/100ul现货Phospho-CUL4B(Thr48) Antibody/Affinity/磷酸化/AF7083/100ul现货

Phospho-CUL4B(Thr48) Antibody/Affinity/磷酸化/AF7083/100ul现货Phospho-CUL4B(Thr48) Antibody/Affinity/磷酸化/AF7083/100ul现货

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