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  • 产品名称:Phospho-TFAP2C(Ser434) Antibody/Affinity/磷酸化/AF7082/100ul现货

  • 产品型号:AF7082
  • 产品厂商:Affinity
  • 产品价格:2500
  • 折扣价格:0
  • 产品文档:
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简单介绍:
Phospho-TFAP2C(Ser434) Antibody/Affinity/磷酸化/AF7082/100ul现货 Affinity全球*全*新磷酸化抗体,可出具HPLC/MS检测报告,WB检测采用封闭钛验证。ELISE保证,IHC验证人大小鼠超过78种不同组织。 Phospho-TFAP2C(Ser434) Antibody/Affinity/磷酸化/AF7082/100ul现货 Phospho-TFAP2C(Ser434) Antibody/Affinity/磷酸化/AF7082/100ul现货
详情介绍:

Phospho-TFAP2C(Ser434) Antibody/Affinity/磷酸化/AF7082/100ul现货


别名:

Activating enhancer binding protein 2 gamma; Activating enhancer-binding protein 2 gamma; AP2-gamma; AP2C_HUMAN; AP2g; AP2gamma; ERF 1; ERF1; Estrogen receptor factor 1; hAP 2g; hAP2g; TFAP 2C; TFAP 2G; Tfap2c; TFAP2G; Transcription factor AP 2 gamma (activating enhancer binding protein 2 gamma); Transcription factor AP 2 gamma; Transcription factor AP-2 gamma; Transcription factor ERF 1; Transcription factor ERF-1; Transcription factor ERF1;

应用:

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

反应种属:

Human,Mouse

纯化:

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

表位:

Phospho-TFAP2C(Ser434) Antibody detects endogenous levels of TFAP2C only when phosphorylated at Ser434

**原:

A synthesized peptide derived from human TFAP2C around the phosphorylation site of Ser434

功能:

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-ted epigenetic regulation of ESR1 expression in breast cancer.

细胞定位:

Cytosol;Mitochondrion;Nucleus;

Extracellular region or secretedCytosolPlasma membraneCytoskeletonLysosomeEndosomePeroxisomeERGolgi apparatusNucleusMitochondrionManual annotationAutomatic computational assertionGraphics by Christian Stolte

翻译后修饰:

Sumoylated on Lys-10; which inhibits transcriptional activity.

组织特异性:

During retinoic acid-ted differentiation.

亚结构:

Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity). Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Interacts with MTA1.

同源性:

The WW-binding motif tes interaction with WWOX.Belongs to the AP-2 family.

Protein BLAST With

蛋白序列:

        10         20         30         40         50
MLWKITDNVK YEEDCEDRHD GSSNGNPRVP HLSSAGQHLY SPAPPLSHTG 
        60         70         80         90        100
VAEYQPPPYF PPPYQQLAYS QSADPYSHLG EAYAAAINPL HQPAPTGSQQ 
       110        120        130        140        150
QAWPGRQSQE GAGLPSHHGR PAGLLPHLSG LEAGAVSARR DAYRRSDLLL 
       160        170        180        190        200
PHAHALDAAG LAENLGLHDM PHQMDEVQNV DDQHLLLHDQ TVIRKGPISM 
       210        220        230        240        250
TKNPLNLPCQ KELVGAVMNP TEVFCSVPGR LSLLSSTSKY KVTVAEVQRR 
       260        270        280        290        300
LSPPECLNAS LLGGVLRRAK SKNGGRSLRE KLDKIGLNLP AGRRKAAHVT 
       310        320        330        340        350
LLTSLVEGEA VHLARDFAYV CEAEFPSKPV AEYLTRPHLG GRNEMAARKN 
       360        370        380        390        400
MLLAAQQLCK EFTELLSQDR TPHGTSRLAP VLETNIQNCL SHFSLITHGF 
       410        420        430        440        450
GSQAICAAVS ALQNYIKEAL IVIDKSYMNP GDQSPADSNK TLEKMEKHRK 

保存说明:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt


Phospho-TFAP2C(Ser434) Antibody/Affinity/磷酸化/AF7082/100ul现货Phospho-TFAP2C(Ser434) Antibody/Affinity/磷酸化/AF7082/100ul现货

Phospho-TFAP2C(Ser434) Antibody/Affinity/磷酸化/AF7082/100ul现货Phospho-TFAP2C(Ser434) Antibody/Affinity/磷酸化/AF7082/100ul现货

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