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  • 产品名称:Phospho-PINK1(Ser228) Antibody/Affinity/磷酸化/AF7081/100ul现货

  • 产品型号:AF7081
  • 产品厂商:Affinity
  • 产品价格:2500
  • 折扣价格:0
  • 产品文档:
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简单介绍:
Phospho-PINK1(Ser228) Antibody/Affinity/磷酸化/AF7081/100ul现货 Affinity全球*全*新磷酸化抗体,可出具HPLC/MS检测报告,WB检测采用封闭钛验证。ELISE保证,IHC验证人大小鼠超过77种不同组织。 Phospho-PINK1(Ser228) Antibody/Affinity/磷酸化/AF7081/100ul现货 Phospho-PINK1(Ser228) Antibody/Affinity/磷酸化/AF7081/100ul现货
详情介绍:

Phospho-PINK1(Ser228) Antibody/Affinity/磷酸化/AF7081/100ul现货


别名:

BRPK; FLJ27236; mitochondrial; PARK 6; PARK6; Phosphatase and Tensin Homolog; PINK 1; PINK1; PINK1_HUMAN; Protein kinase BRPK; PTEN induced putative kinase 1; PTEN induced putative kinase protein 1; PTEN-induced putative kinase protein 1; Serine/threonine kinase PINK1 mitochondrial; Serine/threonine protein kinase PINK1 mitochondrial; Serine/threonine-protein kinase PINK1;

应用:

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

反应种属:

Human,Mouse,Rat

纯化:

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

表位:

Phospho-PINK1(Ser228) Antibody detects endogenous levels of PINK1 only when phosphorylated at Ser228

**原:

A synthesized peptide derived from human PINK1 around the phosphorylation site of Ser228

研究领域:

· Human Diseases > Neurodegenerative diseases > Parkinson's disease

功能:

Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by ting activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by ting phosphorylation at 'Ser-65' of PRKN and (2) ting phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiqui/none reduction by mitochondrial complex I by ting phosphorylation of complex I subunit NDUFA10 (By similarity).

细胞定位:

Cytoskeleton;Cytosol;Mitochondrion;Nucleus;

Extracellular region or secretedCytosolPlasma membraneCytoskeletonLysosomeEndosomePeroxisomeERGolgi apparatusNucleusMitochondrionManual annotationAutomatic computational assertionGraphics by Christian Stolte

翻译后修饰:

Autophosphorylation at Ser-228 and Ser-402 is essential for Parkin/PRKN recruitment to depolarized mitochondria.Two shorter forms of 55 kDa and 48 kDa seem to be produced by proteolytic cleavage and localize mainly in cytosol.

组织特异性:

Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.

亚结构:

Interacts with PRKN. Interacts with FBXO7. Forms a complex with PRKN and PARK7 (PubMed:19229105).

同源性:

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Protein BLAST With

蛋白序列:

        10         20         30         40         50
MAVRQALGRG LQLGRALLLR FTGKPGRAYG LGRPGPAAGC VRGERPGWAA 
        60         70         80         90        100
GPGAEPRRVG LGLPNRLRFF RQSVAGLAAR LQRQFVVRAW GCAGPCGRAV 
       110        120        130        140        150
FLAFGLGLGL IEEKQAESRR AVSACQEIQA IFTQKSKPGP DPLDTRRLQG 
       160        170        180        190        200
FRLEEYLIGQ SIGKGCSAAV YEATMPTLPQ NLEVTKSTGL LPGRGPGTSA 
       210        220        230        240        250
PGEGQERAPG APAFPLAIKM MWNISAGSSS EAILNTMSQE LVPASRVALA 
       260        270        280        290        300
GEYGAVTYRK SKRGPKQLAP HPNIIRVLRA FTSSVPLLPG ALVDYPDVLP 
       310        320        330        340        350
SRLHPEGLGH GRTLFLVMKN YPCTLRQYLC VNTPSPRLAA MMLLQLLEGV 
       360        370        380        390        400
DHLVQQGIAH RDLKSDNILV ELDPDGCPWL VIADFGCCLA DESIGLQLPF 
       410        420        430        440        450
SSWYVDRGGN GCLMAPEVST ARPGPRAVID YSKADAWAVG AIAYEIFGLV 
       460        470        480        490        500
NPFYGQGKAH LESRSYQEAQ LPALPESVPP DVRQLVRALL QREASKRPSA 
       510        520        530        540        550
RVAANVLHLS LWGEHILALK NLKLDKMVGW LLQQSAATLL ANRLTEKCCV 
       560        570        580 
ETKMKMLFLA NLECETLCQA ALLLCSWRAA L            

保存说明:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt


Phospho-PINK1(Ser228) Antibody/Affinity/磷酸化/AF7081/100ul现货Phospho-PINK1(Ser228) Antibody/Affinity/磷酸化/AF7081/100ul现货

Phospho-PINK1(Ser228) Antibody/Affinity/磷酸化/AF7081/100ul现货Phospho-PINK1(Ser228) Antibody/Affinity/磷酸化/AF7081/100ul现货

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