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  • 产品名称:Phospho-MyoD(Thr115) Antibody/Affinity/磷酸化/AF7079/100ul现货

  • 产品型号:AF7079
  • 产品厂商:Affinity
  • 产品价格:2500
  • 折扣价格:0
  • 产品文档:
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简单介绍:
Phospho-MyoD(Thr115) Antibody/Affinity/磷酸化/AF7079/100ul现货 Affinity全球*全*新磷酸化抗体,可出具HPLC/MS检测报告,WB检测采用封闭钛验证。ELISE保证,IHC验证人大小鼠超过75种不同组织。 Phospho-MyoD(Thr115) Antibody/Affinity/磷酸化/AF7079/100ul现货 Phospho-MyoD(Thr115) Antibody/Affinity/磷酸化/AF7079/100ul现货
详情介绍:

Phospho-MyoD(Thr115) Antibody/Affinity/磷酸化/AF7079/100ul现货


别名:

bHLHc1; Class C basic helix-loop-helix protein 1; MYF 3; Myf-3; MYF3; Myoblast determination protein 1; Myod 1; MYOD; MYOD1; MYOD1_HUMAN; Myogenic differentiation 1; Myogenic factor 3; Myogenic factor MYF 3; Myogenin D1; PUM;

应用:

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

反应种属:

Human,Mouse,Rat

纯化:

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

表位:

Phospho-MyoD(Thr115) Antibody detects endogenous levels of MyoD only when phosphorylated at Thr115

**原:

A synthesized peptide derived from human MyoD around the phosphorylation site of Thr115

功能:

Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).

细胞定位:

Cytosol;Nucleus;

Extracellular region or secretedCytosolPlasma membraneCytoskeletonLysosomeEndosomePeroxisomeERGolgi apparatusNucleusMitochondrionManual annotationAutomatic computational assertionGraphics by Christian Stolte

翻译后修饰:

Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation.Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function (By similarity).Ubiquitinated on the N-terminus; which is required for proteasomal degradation.Methylation at Lys-104 by EHMT2/G9a inhibits myogenic activity.

亚结构:

Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1. Interacts with DDX5. Interacts with CHD2. Interacts with TSC22D3 (By similarity). Interacts with SETD3 (By similarity). Interacts with P-TEFB complex; promotes the transcriptional activity of MYOD1 through its CDK9-ted phosphorylation (By similarity) (PubMed:12037670). Interacts with CSRP3.

Protein BLAST With

蛋白序列:

        10         20         30         40         50
MELLSPPLRD VDLTAPDGSL CSFATTDDFY DDPCFDSPDL RFFEDLDPRL 
        60         70         80         90        100
MHVGALLKPE EHSHFPAAVH PAPGAREDEH VRAPSGHHQA GRCLLWACKA 
       110        120        130        140        150
CKRKTTNADR RKAATMRERR RLSKVNEAFE TLKRCTSSNP NQRLPKVEIL 
       160        170        180        190        200
RNAIRYIEGL QALLRDQDAA PPGAAAAFYA PGPLPPGRGG EHYSGDSDAS 
       210        220        230        240        250
SPRSNCSDGM MDYSGPPSGA RRRNCYEGAY YNEAPSEPRP GKSAAVSSLD 
       260        270        280        290        300
CLSSIVERIS TESPAAPALL LADVPSESPP RRQEAAAPSE GESSGDPTQS 
       310        320
PDAAPQCPAG ANPNPIYQVL                                  

保存说明:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt


Phospho-MyoD(Thr115) Antibody/Affinity/磷酸化/AF7079/100ul现货Phospho-MyoD(Thr115) Antibody/Affinity/磷酸化/AF7079/100ul现货

Phospho-MyoD(Thr115) Antibody/Affinity/磷酸化/AF7079/100ul现货Phospho-MyoD(Thr115) Antibody/Affinity/磷酸化/AF7079/100ul现货

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