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  • 产品名称:Phospho-CASP2(Ser340) Antibody/Affinity/磷酸化/AF7078/100ul现货

  • 产品型号:AF7078
  • 产品厂商:Affinity
  • 产品价格:2500
  • 折扣价格:0
  • 产品文档:
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简单介绍:
Phospho-CASP2(Ser340) Antibody/Affinity/磷酸化/AF7078/100ul现货 Affinity全球*全*新磷酸化抗体,可出具HPLC/MS检测报告,WB检测采用封闭钛验证。ELISE保证,IHC验证人大小鼠超过74种不同组织。 Phospho-CASP2(Ser340) Antibody/Affinity/磷酸化/AF7078/100ul现货 Phospho-CASP2(Ser340) Antibody/Affinity/磷酸化/AF7078/100ul现货
详情介绍:

Phospho-CASP2(Ser340) Antibody/Affinity/磷酸化/AF7078/100ul现货


别名:

CASP 2; CASP-2; Casp2; CASP2_HUMAN; Caspase 2; Caspase 2 apoptosis related cysteine peptidase; Caspase-2 subunit p12; Caspase2; ICH 1; ICH 1 protease; ICH 1L; ICH1; ICH1 protease; ICH1L; NEDD-2; NEDD2; Neural precursor cell expressed developmentally down-regulated protein 2; PPP1R57; Protease ICH-1; Protein phosphatase 1 regulatory subunit 57;

应用:

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

反应种属:

Human,Mouse,Rat

纯化:

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

表位:

Phospho-CASP2(Ser340) Antibody detects endogenous levels of CASP2 only when phosphorylated at Ser340

**原:

A synthesized peptide derived from human CASP2 around the phosphorylation site of Ser340

研究领域:

· Cellular Processes > Cell growth and death > Apoptosis(查看通路图)

功能:

Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.

细胞定位:

Cytosol;Mitochondrion;Nucleus;

Extracellular region or secretedCytosolPlasma membraneCytoskeletonLysosomeEndosomePeroxisomeERGolgi apparatusNucleusMitochondrionManual annotationAutomatic computational assertionGraphics by Christian Stolte

翻译后修饰:

The mature protease can process its own propeptide, but not that of other caspases.

组织特异性:

Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In *****s, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.

亚结构:

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD. Interacts with NOL3 (via CARD domain); inhibits CASP2 activity in a phosphorylation-dependent manner.

同源性:

Belongs to the peptidase C14A family.

Protein BLAST With

蛋白序列:

        10         20         30         40         50
MAAPSAGSWS TFQHKELMAA DRGRRILGVC GMHPHHQETL KKNRVVLAKQ 
        60         70         80         90        100
LLLSELLEHL LEKDIITLEM RELIQAKVGS FSQNVELLNL LPKRGPQAFD 
       110        120        130        140        150
AFCEALRETK QGHLEDMLLT TLSGLQHVLP PLSCDYDLSL PFPVCESCPL 
       160        170        180        190        200
YKKLRLSTDT VEHSLDNKDG PVCLQVKPCT PEFYQTHFQL AYRLQSRPRG 
       210        220        230        240        250
LALVLSNVHF TGEKELEFRS GGDVDHSTLV TLFKLLGYDV HVLCDQTAQE 
       260        270        280        290        300
MQEKLQNFAQ LPAHRVTDSC IVALLSHGVE GAIYGVDGKL LQLQEVFQLF 
       310        320        330        340        350
DNANCPSLQN KPKMFFIQAC RGDETDRGVD QQDGKNHAGS PGCEESDAGK 
       360        370        380        390        400
EKLPKMRLPT RSDMICGYAC LKGTAAMRNT KRGSWYIEAL AQVFSERACD 
       410        420        430        440        450
MHVADMLVKV NALIKDREGY APGTEFHRCK EMSEYCSTLC RHLYLFPGHP 
PT                                             

保存说明:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt


Phospho-CASP2(Ser340) Antibody/Affinity/磷酸化/AF7078/100ul现货Phospho-CASP2(Ser340) Antibody/Affinity/磷酸化/AF7078/100ul现货

Phospho-CASP2(Ser340) Antibody/Affinity/磷酸化/AF7078/100ul现货Phospho-CASP2(Ser340) Antibody/Affinity/磷酸化/AF7078/100ul现货

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