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  • 产品名称:Phospho-TXN(Thr100) Antibody/Affinity/磷酸化/AF7077/100ul现货

  • 产品型号:AF7077
  • 产品厂商:Affinity
  • 产品价格:2500
  • 折扣价格:0
  • 产品文档:
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简单介绍:
Phospho-TXN(Thr100) Antibody/Affinity/磷酸化/AF7077/100ul现货 Affinity全球*全*新磷酸化抗体,可出具HPLC/MS检测报告,WB检测采用封闭钛验证。ELISE保证,IHC验证人大小鼠超过73种不同组织。 Phospho-TXN(Thr100) Antibody/Affinity/磷酸化/AF7077/100ul现货 Phospho-TXN(Thr100) Antibody/Affinity/磷酸化/AF7077/100ul现货
详情介绍:

Phospho-TXN(Thr100) Antibody/Affinity/磷酸化/AF7077/100ul现货


别名:

ADF; ATL derived factor; ATL-derived factor; DKFZp686B1993; MGC61975; SASP; Surface associated sulphydryl protein; Surface-associated sulphydryl protein; testicular tissue protein Li 199; THIO_HUMAN; Thioredoxin; thioredoxin delta 3; TRDX; TRX 1; Trx; TRX1; TXN; TXN delta 3; TXN protein; zgc:92903;

应用:

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

反应种属:

Human,Mouse,Rat

纯化:

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

表位:

Phospho-TXN(Thr100) Antibody detects endogenous levels of TXN only when phosphorylated at Thr100

**原:

A synthesized peptide derived from human TXN around the phosphorylation site of Thr100

研究领域:

· Organismal Systems > Immune system > NOD-like receptor signaling pathway(查看通路图)

功能:

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.

细胞定位:

Cytosol;Extracellular region or secreted;Mitochondrion;Nucleus;

Extracellular region or secretedCytosolPlasma membraneCytoskeletonLysosomeEndosomePeroxisomeERGolgi apparatusNucleusMitochondrionManual annotationAutomatic computational assertionGraphics by Christian Stolte

翻译后修饰:

In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins.In case of infection, ubiquitinated by S.typhimurium protein slrP, leading to its degradation.

组织特异性:

Up-regulated by ionizing radiation.

亚结构:

Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. In case of infection, interacts with S.typhimurium protein slrP. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner.

同源性:

Belongs to the thioredoxin family.

Protein BLAST With

蛋白序列:

        10         20         30         40         50
MVKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS 
        60         70         80         90        100
NVIFLEVDVD DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT 
INELV                                             

保存说明:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt


Phospho-TXN(Thr100) Antibody/Affinity/磷酸化/AF7077/100ul现货Phospho-TXN(Thr100) Antibody/Affinity/磷酸化/AF7077/100ul现货

Phospho-TXN(Thr100) Antibody/Affinity/磷酸化/AF7077/100ul现货Phospho-TXN(Thr100) Antibody/Affinity/磷酸化/AF7077/100ul现货

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