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  • 产品名称:Phospho-USP22(Thr147) Antibody/Affinity/磷酸化/AF7076/100ul现货

  • 产品型号:AF7076
  • 产品厂商:Affinity
  • 产品价格:2500
  • 折扣价格:0
  • 产品文档:
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简单介绍:
Phospho-USP22(Thr147) Antibody/Affinity/磷酸化/AF7076/100ul现货 Affinity全球*全*新磷酸化抗体,可出具HPLC/MS检测报告,WB检测采用封闭钛验证。ELISE保证,IHC验证人大小鼠超过72种不同组织。 Phospho-USP22(Thr147) Antibody/Affinity/磷酸化/AF7076/100ul现货 Phospho-USP22(Thr147) Antibody/Affinity/磷酸化/AF7076/100ul现货
详情介绍:

Phospho-USP22(Thr147) Antibody/Affinity/磷酸化/AF7076/100ul现货


别名:

Deubiquitinating enzyme 22; KIAA1063; Ubiquitin carboxyl terminal hydrolase 22; Ubiquitin carboxyl-terminal hydrolase 22; Ubiquitin specific peptidase 22; Ubiquitin specific peptidase 3 like; Ubiquitin specific processing protease 22; Ubiquitin specific protease 22; Ubiquitin thioesterase 22; Ubiquitin thiolesterase 22; Ubiquitin-specific-processing protease 22; UBP22_HUMAN; USP 22; Usp22; USP3L;

应用:

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

反应种属:

Human,Mouse,Rat

纯化:

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

表位:

Phospho-USP22(Thr147) Antibody detects endogenous levels of USP22 only when phosphorylated at Thr147

**原:

A synthesized peptide derived from human USP22 around the phosphorylation site of Thr147

功能:

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-ted transactivation and cell cycle progression.

细胞定位:

Nucleus;

Extracellular region or secretedCytosolPlasma membraneCytoskeletonLysosomeEndosomePeroxisomeERGolgi apparatusNucleusMitochondrionManual annotationAutomatic computational assertionGraphics by Christian Stolte

组织特异性:

Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver.

亚结构:

Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitination. Interacts directly with ATXN7L3; leading to its recritment to the SAGA complex.

同源性:

Belongs to the peptidase C19 family. UBP8 subfamily.

Protein BLAST With

蛋白序列:

        10         20         30         40         50
MVSRPEPEGE AMDAELAVAP PGCSHLGSFK VDNWKQNLRA IYQCFVWSGT 
        60         70         80         90        100
AEARKRKAKS CICHVCGVHL NRLHSCLYCV FFGCFTKKHI HEHAKAKRHN 
       110        120        130        140        150
LAIDLMYGGI YCFLCQDYIY DKDMEIIAKE EQRKAWKMQG VGEKFSTWEP 
       160        170        180        190        200
TKRELELLKH NPKRRKITSN CTIGLRGLIN LGNTCFMNCI VQALTHTPLL 
       210        220        230        240        250
RDFFLSDRHR CEMQSPSSCL VCEMSSLFQE FYSGHRSPHI PYKLLHLVWT 
       260        270        280        290        300
HARHLAGYEQ QDAHEFLIAA LDVLHRHCKG DDNGKKANNP NHCNCIIDQI 
       310        320        330        340        350
FTGGLQSDVT CQVCHGVSTT IDPFWDISLD LPGSSTPFWP LSPGSEGNVV 
       360        370        380        390        400
NGESHVSGTT TLTDCLRRFT RPEHLGSSAK IKCSGCHSYQ ESTKQLTMKK 
       410        420        430        440        450
LPIVACFHLK RFEHSAKLRR KITTYVSFPL ELDMTPFMAS SKESRMNGQY 
       460        470        480        490        500
QQPTDSLNND NKYSLFAVVN HQGTLESGHY TSFIRQHKDQ WFKCDDAIIT 
       510        520 
KASIKDVLDS EGYLLFYHKQ FLEYE                       

保存说明:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt


Phospho-USP22(Thr147) Antibody/Affinity/磷酸化/AF7076/100ul现货Phospho-USP22(Thr147) Antibody/Affinity/磷酸化/AF7076/100ul现货

Phospho-USP22(Thr147) Antibody/Affinity/磷酸化/AF7076/100ul现货Phospho-USP22(Thr147) Antibody/Affinity/磷酸化/AF7076/100ul现货

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