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  • 产品名称:Phospho-HES1(Ser339) Antibody/Affinity/磷酸化/AF7075/100ul现货

  • 产品型号:AF7075
  • 产品厂商:Affinity
  • 产品价格:2500
  • 折扣价格:0
  • 产品文档:
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简单介绍:
Phospho-HES1(Ser339) Antibody/Affinity/磷酸化/AF7075/100ul现货 Affinity全球*全*新磷酸化抗体,可出具HPLC/MS检测报告,WB检测采用封闭钛验证。ELISE保证,IHC验证人大小鼠超过71种不同组织。 Phospho-HES1(Ser339) Antibody/Affinity/磷酸化/AF7075/100ul现货 Phospho-HES1(Ser339) Antibody/Affinity/磷酸化/AF7075/100ul现货
详情介绍:

Phospho-HES1(Ser339) Antibody/Affinity/磷酸化/AF7075/100ul现货


别名:

bHLHb39; C-HAIRY1; c-hairy1A; Class B basic helix-loop-helix protein 39; FLJ20408; Hairy and enhancer of split 1 (Drosophila); Hairy and enhancer of split 1; Hairy homolog (Drosophila); Hairy homolog; Hairy like; Hairy, Drosophila, homolog of; Hairy-like protein; Hairy/enhancer of split, Drosophila, homolog of, 1; HAIRY1; HES-1; hes1; Hes1 hairy and enhancer of split 1 (Drosophila); HES1_HUMAN; HHL; HL; HRY; MGC129109; OTTHUMP00000209031; RHL; Transcription factor HES-1;

应用:

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

反应种属:

Human,Mouse,Rat

纯化:

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

表位:

Phospho-HES1(Ser339) Antibody detects endogenous levels of HES1 only when phosphorylated at Ser339

**原:

A synthesized peptide derived from human HES1 around the phosphorylation site of Ser339

研究领域:

· Environmental Inion Processing > Signal transduction > Notch signaling pathway(查看通路图)
· Genetic Inion Processing > Replication and repair > Fanconi anemia pathway
· Human Diseases > Cancers: Overview > Pathways in cancer(查看通路图)
· Human Diseases > Endocrine and metabolic diseases > Maturity onset diabetes of the young
· Human Diseases > Cancers: Specific types > Breast cancer(查看通路图)
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection

功能:

Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.

细胞定位:

Nucleus;

Extracellular region or secretedCytosolPlasma membraneCytoskeletonLysosomeEndosomePeroxisomeERGolgi apparatusNucleusMitochondrionManual annotationAutomatic computational assertionGraphics by Christian Stolte

亚结构:

Transcription repression requires ion of a complex with a corepressor protein of the Groucho/TLE family. Interacts (via WPRW motif) with TLE1, and more weakly with TLE2. Interacts with HES6 (By similarity). Interacts with SIRT1. Interacts with an FA complex, composed of FANCA, FANCF, FANCG and FANCL, but not of FANCC, nor FANCE.

同源性:

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.The bHLH, as well as cooperation between the central Orange domain and the C-terminal WRPW motif, is required for transcriptional repressor activity.

Protein BLAST With

蛋白序列:

        10         20         30         40         50
MPADIMEKNS SSPVAATPAS VNTTPDKPKT ASEHRKSSKP IMEKRRRARI 
        60         70         80         90        100
NESLSQLKTL ILDALKKDSS RHSKLEKADI LEMTVKHLRN LQRAQMTAAL 
       110        120        130        140        150
STDPSVLGKY RAGFSECMNE VTRFLSTCEG VNTEVRTRLL GHLANCMTQI 
       160        170        180        190        200
NAMTYPGQPH PALQAPPPPP PGPGGPQHAP FAPPPPLVPI PGGAAPPPGG 
       210        220        230        240        250
APCKLGSQAG EAAKVFGGFQ VVPAPDGQFA FLIPNGAFAH SGPVIPVYTS 
       260        270        280
NSGTSVGPNA VSPSSGPSLT ADSMWRPWRN                       

保存说明:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt


Phospho-HES1(Ser339) Antibody/Affinity/磷酸化/AF7075/100ul现货Phospho-HES1(Ser339) Antibody/Affinity/磷酸化/AF7075/100ul现货

Phospho-HES1(Ser339) Antibody/Affinity/磷酸化/AF7075/100ul现货Phospho-HES1(Ser339) Antibody/Affinity/磷酸化/AF7075/100ul现货

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