智慧彩票

产品详情
  • 产品名称:Phospho-GLI2(Ser234) Antibody/Affinity/磷酸化/AF7072/100ul现货

  • 产品型号:AF7072
  • 产品厂商:Affinity
  • 产品价格:2500
  • 折扣价格:0
  • 产品文档:
你添加了1件商品 查看购物车
简单介绍:
Phospho-GLI2(Ser234) Antibody/Affinity/磷酸化/AF7072/100ul现货 Affinity全球*全*新磷酸化抗体,可出具HPLC/MS检测报告,WB检测采用封闭钛验证。ELISE保证,IHC验证人大小鼠超过68种不同组织。 Phospho-GLI2(Ser234) Antibody/Affinity/磷酸化/AF7072/100ul现货 Phospho-GLI2(Ser234) Antibody/Affinity/磷酸化/AF7072/100ul现货
详情介绍:

Phospho-GLI2(Ser234) Antibody/Affinity/磷酸化/AF7072/100ul现货


应用:

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

反应种属:

Human

纯化:

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

表位:

Phospho-GLI2(Ser234) Antibody detects endogenous levels of GLI2 only when phosphorylated at Ser234

**原:

A synthesized peptide derived from human GLI2 around the phosphorylation site of Ser234

研究领域:

· Environmental Inion Processing > Signal transduction > Hippo signaling pathway(查看通路图)
· Environmental Inion Processing > Signal transduction > Hedgehog signaling pathway(查看通路图)
· Human Diseases > Cancers: Specific types > Basal cell carcinoma(查看通路图)
· Human Diseases > Cancers: Overview > Pathways in cancer(查看通路图)

功能:

Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856).

细胞定位:

Cytoskeleton;Cytosol;Nucleus;

Extracellular region or secretedCytosolPlasma membraneCytoskeletonLysosomeEndosomePeroxisomeERGolgi apparatusNucleusMitochondrionManual annotationAutomatic computational assertionGraphics by Christian Stolte

翻译后修饰:

Phosphorylated in vitro by ULK3. Phosphorylated by DYRK2; this inhibits GLI2 transcription factor activity and promotes proteasomal degradation of GLI2.Acetylation at Lys-757 inhibits Hh target gene expression, probably by impeding entry into chromatin thus preventing promoter occupancy.

组织特异性:

Isoform 1 and isoform 4 are expressed in HTLV-1-infected T-cell lines (at protein level). Isoform 1 and isoform 2 are strongly expressed in HTLV-1-infected T-cell lines. Isoform 3 and isoform 4 are weakly expressed in HTLV-1-infected T-cell lines.

亚结构:

Interaction with ZIC1 and ZIC2 (By similarity). Interacts with STK36 (PubMed:10806483). Interacts with SUFU; this inhibits transcriptional activation ted by GLI2 (PubMed:24311597).

同源性:

The N-terminal domain confers transcriptional repressor activity, while the C-terminal domain tes transcriptional activation.Belongs to the GLI C2H2-type zinc-finger protein family.

Protein BLAST With

蛋白序列:

        10         20         30         40         50
METSASATAS EKQEAKSGIL EAAGFPDPGK KASPLVVAAA AAAAVAAQGV 
        60         70         80         90        100
PQHLLPPFHA PLPIDMRHQE GRYHYEPHSV HGVHGPPALS GSPVISDISL 
       110        120        130        140        150
IRLSPHPAGP GESPFNAPHP YVNPHMEHYL RSVHSSPTLS MISAARGLSP 
       160        170        180        190        200
ADVAQEHLKE RGLFGLPAPG TTPSDYYHQM TLVAGHPAPY GDLLMQSGGA 
       210        220        230        240        250
ASAPHLHDYL NPVDVSRFSS PRVTPRLSRK RALSISPLSD ASLDLQRMIR 
       260        270        280        290        300
TSPNSLVAYI NNSRSSSAAS GSYGHLSAGA LSPAFTFPHP INPVAYQQIL 
       310        320        330        340        350
SQQRGLGSAF GHTPPLIQPS PTFLAQQPMA LTSINATPTQ LSSSSNCLSD 
       360        370        380        390        400
TNQNKQSSES AVSSTVNPVA IHKRSKVKTE PEGLRPASPL ALTQGQVSGH 
       410        420        430        440        450
GSCGCALPLS QEQLADLKED LDRDDCKQEA EVVIYETNCH WEDCTKEYDT 
       460        470        480        490        500
QEQLVHHINN EHIHGEKKEF VCRWQACTRE QKPFKAQYML VVHMRRHTGE 
       510        520        530        540        550
KPHKCTFEGC SKAYSRLENL KTHLRSHTGE KPYVCEHEGC NKAFSNASDR 
       560        570        580        590        600
AKHQNRTHSN EKPYICKIPG CTKRYTDPSS LRKHVKTVHG PDAHVTKKQR 
       610        620        630        640        650
NDVHLRTPLL KENGDSEAGT EPGGPESTEA SSTSQAVEDC LHVRAIKTES 
       660        670        680        690        700
SGLCQSSPGA QSSCSSEPSP LGSAPNNDSG VEMPGTGPGS LGDLTALDDT 
       710        720        730        740        750
PPGADTSALA APSAGGLQLR KHMTTMHRFE QLKKEKLKSL KDSCSWAGPT 
       760        770        780        790        800
PHTRNTKLPP LPGSGSILEN FSGSGGGGPA GLLPNPRLSE LSASEVTMLS 
       810        820        830        840        850
QLQERRDSST STVSSAYTVS RRSSGISPYF SSRRSSEASP LGAGRPHNAS 
       860        870        880        890        900
SADSYDPIST DASRRSSEAS QCSGGSGLLN LTPAQQYSLR AKYAAATGGP 
       910        920        930        940        950
PPTPLPGLER MSLRTRLALL DAPERTLPAG CPRPLGPRRG SDGPTYGHGH 
       960        970        980        990       1000
AGAAPAFPHE APGGGARRAS DPVRRPDALS LPRVQRFHST HNVNPGPLPP 
      1010       1020       1030       1040       1050
CADRRGLRLQ SHPSTDGGLA RGAYSPRPPS ISENVAMEAV AAGVDGAGPE 
      1060       1070       1080       1090       1100
ADLGLPEDDL VLPDDVVQYI KAHASGALDE GTGQVYPTES TGFSDNPRLP 
      1110       1120       1130       1140       1150
SPGLHGQRRM VAADSNVGPS APMLGGCQLG FGAPSSLNKN NMPVQWNEVS 
      1160       1170       1180       1190       1200
SGTVDALASQ VKPPPFPQGN LAVVQQKPAF GQYPGYSPQG LQASPGGLDS 
      1210       1220       1230       1240       1250
TQPHLQPRSG APSQGIPRVN YMQQLRQPVA GSQCPGMTTT MSPHACYGQV 
      1260       1270       1280       1290       1300
HPQLSPSTIS GALNQFPQSC SNMPAKPGHL GHPQQTEVAP DPTTMGNRHR 
      1310       1320       1330       1340       1350
ELGVPDSALA GVPPPHPVQS YPQQSHHLAA SMSQEGYHQV PSLLPARQPG 
      1360       1370       1380       1390       1400
FMEPQTGPMG VATAGFGLVQ PRPPLEPSPT GRHRGVRAVQ QQLAYARATG 
      1410       1420       1430       1440       1450
HAMAAMPSSQ ETAEAVPKGA MGNMGSVPPQ PPPQDAGGAP DHSMLYYYGQ 
      1460       1470       1480       1490       1500
IHMYEQDGGL ENLGSCQVMR SQPPQPQACQ DSIQPQPLPS PGVNQVSSTV 
      1510       1520       1530       1540       1550
DSQLLEAPQI DFDAIMDDGD HSSLFSGALS PSLLHSLSQN SSRLTTPRNS 
      1560       1570       1580 
LTLPSIPAGI SNMAVGDMSS MLTSLAEESK FLNMMT            

保存说明:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt


Phospho-GLI2(Ser234) Antibody/Affinity/磷酸化/AF7072/100ul现货Phospho-GLI2(Ser234) Antibody/Affinity/磷酸化/AF7072/100ul现货

Phospho-GLI2(Ser234) Antibody/Affinity/磷酸化/AF7072/100ul现货Phospho-GLI2(Ser234) Antibody/Affinity/磷酸化/AF7072/100ul现货

相关信息
标题:
内容:
联系人:
联系电话:
Email:
公司名称:
联系地址:
 
 
注:1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

苏公网安备 32011202000132号

友情链接:五分彩  一分彩  三分彩官网  一分彩  一分彩  三分彩  三分彩  

免责声明: 本站资料及图片来源互联网文章,本网不承担任何由内容信息所引起的争议和法律责任。所有作品版权归原创作者所有,与本站立场无关,如用户分享不慎侵犯了您的权益,请联系我们告知,我们将做删除处理!