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  • 产品名称:Phospho-GLI1(Thr1074) Antibody/Affinity/磷酸化/AF7070/100ul现货

  • 产品型号:AF7070
  • 产品厂商:Affinity
  • 产品价格:2500
  • 折扣价格:0
  • 产品文档:
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简单介绍:
Phospho-GLI1(Thr1074) Antibody/Affinity/磷酸化/AF7070/100ul现货 Affinity全球*全*新磷酸化抗体,可出具HPLC/MS检测报告,WB检测采用封闭钛验证。ELISE保证,IHC验证人大小鼠超过66种不同组织。 Phospho-GLI1(Thr1074) Antibody/Affinity/磷酸化/AF7070/100ul现货 Phospho-GLI1(Thr1074) Antibody/Affinity/磷酸化/AF7070/100ul现货
详情介绍:

Phospho-GLI1(Thr1074) Antibody/Affinity/磷酸化/AF7070/100ul现货


别名:

Gli 1; GLI; GLI family zinc finger 1; GLI Kruppel family member 1; gli1; GLI1_HUMAN; Glioma associated oncogene 1; Glioma associated oncogene homolog 1 (zinc finger protein); Glioma associated oncogene homolog; Glioma-associated oncogene; Oncogene GLI; Zfp 5; Zfp5; Zinc finger protein GLI 1; Zinc finger protein GLI1;

应用:

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

反应种属:

Human,Mouse

纯化:

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

表位:

Phospho-GLI1(Thr1074) Antibody detects endogenous levels of GLI1 only when phosphorylated at Thr1074

**原:

A synthesized peptide derived from human GLI1 around the phosphorylation site of Thr1074

研究领域:

· Environmental Inion Processing > Signal transduction > Hedgehog signaling pathway(查看通路图)
· Environmental Inion Processing > Signal transduction > cAMP signaling pathway(查看通路图)
· Human Diseases > Cancers: Specific types > Basal cell carcinoma(查看通路图)
· Human Diseases > Cancers: Overview > Pathways in cancer(查看通路图)

功能:

Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). May regulate the transcription of specific genes during normal development (PubMed:19706761). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761). Plays a role in cell proliferation and differentiation via its role in SHH signaling (Probable).

细胞定位:

Cytoskeleton;Cytosol;Nucleus;

Extracellular region or secretedCytosolPlasma membraneCytoskeletonLysosomeEndosomePeroxisomeERGolgi apparatusNucleusMitochondrionManual annotationAutomatic computational assertionGraphics by Christian Stolte

翻译后修饰:

Phosphorylated in vitro by ULK3.Acetylation at Lys-518 down-regulates transcriptional activity. Deacetylated by HDAC1.

组织特异性:

Detected in testis (at protein level) (PubMed:2105456). Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract (PubMed:19878745). Isoform 1 is detected in brain, spleen, pancreas, liver, kidney and placenta; isoform 2 is not detectable in these tissues (PubMed:19706761).

亚结构:

Interacts with KIF7 (By similarity). Interacts with STK36 (PubMed:10806483). Interacts with ZIC1; the interaction enhances transcription activation (PubMed:11238441). Interacts with SUFU; this inhibits transcriptional activation by GLI1 (PubMed:10806483, PubMed:24311597, PubMed:24217340).

同源性:

Belongs to the GLI C2H2-type zinc-finger protein family.

Protein BLAST With

蛋白序列:

        10         20         30         40         50
MFNSMTPPPI SSYGEPCCLR PLPSQGAPSV GTEGLSGPPF CHQANLMSGP 
        60         70         80         90        100
HSYGPARETN SCTEGPLFSS PRSAVKLTKK RALSISPLSD ASLDLQTVIR 
       110        120        130        140        150
TSPSSLVAFI NSRCTSPGGS YGHLSIGTMS PSLGFPAQMN HQKGPSPSFG 
       160        170        180        190        200
VQPCGPHDSA RGGMIPHPQS RGPFPTCQLK SELDMLVGKC REEPLEGDMS 
       210        220        230        240        250
SPNSTGIQDP LLGMLDGRED LEREEKREPE SVYETDCRWD GCSQEFDSQE 
       260        270        280        290        300
QLVHHINSEH IHGERKEFVC HWGGCSRELR PFKAQYMLVV HMRRHTGEKP 
       310        320        330        340        350
HKCTFEGCRK SYSRLENLKT HLRSHTGEKP YMCEHEGCSK AFSNASDRAK 
       360        370        380        390        400
HQNRTHSNEK PYVCKLPGCT KRYTDPSSLR KHVKTVHGPD AHVTKRHRGD 
       410        420        430        440        450
GPLPRAPSIS TVEPKREREG GPIREESRLT VPEGAMKPQP SPGAQSSCSS 
       460        470        480        490        500
DHSPAGSAAN TDSGVEMTGN AGGSTEDLSS LDEGPCIAGT GLSTLRRLEN 
       510        520        530        540        550
LRLDQLHQLR PIGTRGLKLP SLSHTGTTVS RRVGPPVSLE RRSSSSSSIS 
       560        570        580        590        600
SAYTVSRRSS LASPFPPGSP PENGASSLPG LMPAQHYLLR ARYASARGGG 
       610        620        630        640        650
TSPTAASSLD RIGGLPMPPW RSRAEYPGYN PNAGVTRRAS DPAQAADRPA 
       660        670        680        690        700
PARVQRFKSL GCVHTPPTVA GGGQNFDPYL PTSVYSPQPP SITENAAMDA 
       710        720        730        740        750
RGLQEEPEVG TSMVGSGLNP YMDFPPTDTL GYGGPEGAAA EPYGARGPGS 
       760        770        780        790        800
LPLGPGPPTN YGPNPCPQQA SYPDPTQETW GEFPSHSGLY PGPKALGGTY 
       810        820        830        840        850
SQCPRLEHYG QVQVKPEQGC PVGSDSTGLA PCLNAHPSEG PPHPQPLFSH 
       860        870        880        890        900
YPQPSPPQYL QSGPYTQPPP DYLPSEPRPC LDFDSPTHST GQLKAQLVCN 
       910        920        930        940        950
YVQSQQELLW EGGGREDAPA QEPSYQSPKF LGGSQVSPSR AKAPVNTYGP 
       960        970        980        990       1000
GFGPNLPNHK SGSYPTPSPC HENFVVGANR ASHRAAAPPR LLPPLPTCYG 
      1010       1020       1030       1040       1050
PLKVGGTNPS CGHPEVGRLG GGPALYPPPE GQVCNPLDSL DLDNTQLDFV 
      1060       1070       1080       1090       1100
AILDEPQGLS PPPSHDQRGS SGHTPPPSGP PNMAVGNMSV LLRSLPGETE 
FLNSSA                                             

保存说明:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt


Phospho-GLI1(Thr1074) Antibody/Affinity/磷酸化/AF7070/100ul现货Phospho-GLI1(Thr1074) Antibody/Affinity/磷酸化/AF7070/100ul现货

Phospho-GLI1(Thr1074) Antibody/Affinity/磷酸化/AF7070/100ul现货Phospho-GLI1(Thr1074) Antibody/Affinity/磷酸化/AF7070/100ul现货

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